Infection of Immunodeficient Horses with Sarcocystis neurona Does Not Result in Neurologic Disease
نویسندگان
چکیده
منابع مشابه
Infection of immunodeficient horses with Sarcocystis neurona does not result in neurologic disease.
Equine protozoal myeloencephalitis is a progressive neurologic disease of horses most commonly caused by infection with the apicomplexan parasite Sarcocystis neurona. Factors affecting neuroinvasion and neurovirulence have not been determined. We investigated the pathogenesis of infection with S. neurona in horses with severe combined immune deficiency (SCID). Two immunocompetent (IC) Arabian h...
متن کاملDepletion of natural killer cells does not result in neurologic disease due to Sarcocystis neurona in mice with severe combined immunodeficiency.
Sarcocystis neurona is an apicomplexan parasite that is the primary etiologic agent of equine protozoal myeloencephalitis in horses. Protective immune responses in horses have not been determined, but interferon-gamma (IFN-gamma) is considered critical for protection from neurologic disease in mice. The role of adaptive and innate immune responses in control of parasites was explored by infecti...
متن کاملResponse of Horses Exposed to Sarcocystis neurona When Monitored Biweekly
The incubation period of equine protozoal myeloencephalitis may be highly variable and horses may not always develop clinical signs after confirmed exposure. Horses appear to require other risk factors in addition to exposure to Sarcocystis neurona in order to develop clinical signs. Repeated exposures may be protective. Authors’ addresses: College of Veterinary Medicine, Depts. of Veterinary P...
متن کاملEffects of Experimental Sarcocystis neurona-Induced Infection on Immunity in an Equine Model
Sarcocystis neurona is the most common cause of Equine Protozoal Myeloencephalitis (EPM), affecting 0.5-1% horses in the United States during their lifetimes. The objective of this study was to evaluate the equine immune responses in an experimentally induced Sarcocystis neurona infection model. Neurologic parameters were recorded prior to and throughout the 70-day study by blinded investigator...
متن کاملExperimental Infection of Horses with Culture-Derived Sarcocystis neurona Merozoites as a Model for Equine Protozoal Myeloencephalitis
A study was designed to develop an experimental model to produce Sarcocystis neurona encephalitis in horses. Sarcocystis neurona, isolated from the spinal cord of an ataxic horse, was placed in continuous culture using bovine turbinate cells, and the cultured S. neurona merozoites were used to infect lymphocytes. A horse that was subsequently experimentally infected with 100,000 of the S. neuro...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2004
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cdli.11.6.1134-1139.2004